IS THERAPEUTIC DRUG MONITORING RELEVANT FOR ANTIDEPRESSANT DRUG THERAPY? IMPLICATIONS FROM A SYSTEMATIC REVIEW AND META-ANALYSIS WITH FOCUS ON MODERATING FACTORS

Inter-individual differences in antidepressant drug concentrations attained in blood may limit the efficacy of pharmacological treatment of depressive disorders.Therapeutic drug monitoring (TDM) enables to determine drug concentrations in blood and adjust antidepressant dosage accordingly.However, research on the underlying assumption of TDM, assoc

There is an interesting collection of manuscripts from the parish church of St.James in Brno.This collection covers a continuous read more period from early years of the church in 13th century up to early modern time.The collection has been preserved relatively untouched up to these days which is important and quite rare fact.Today it contains 127

Was previously discovered that in the leech Hirudo medicinalis, acetyl-l-carnitine (ALC) affects forms of non-associative learning, such as sensitization and dishabituation, due to nociceptive stimulation of the dorsal skin in the swim induction behavioural paradigm, likely through modulating the activity of the mechanosensory tactile (T) here neur

In response to increasing ecosystems degradation, many mountain countries have recently implemented harm-reduction policy measures in order to sustain their future economic development, which is partially dependent on a strong tourism sector.The objective of this article is to evaluate the policies that stem from Metropolitan Public Gardens Associa

Wrap-around packaging is widely used in logistics and transportation packaging.The development of a self-propelled winding and packaging robot can significantly push up the technological progress of the industry, and the key to the development of this robot is the design of the packaging film fixing device.In this study, we propose a packaging film